| Title: Occurrence, in Crohn's disease, of antibodies directed against a species-specific recombinant polypeptide of Mycobacterium paratuberculosis.
| | Title Abreviation: Clin Diagn Lab Immunol
| Date of Pub: 1994 Mar
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| Author: Vannuffel P; Dieterich C; Naerhuyzen B; Gilot P; Coene M; Fiasse R; Cocito C;
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| Issue/Part/Supplement: 2
| Volume Issue: 1
| Pagination: 241-3
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| MESH Headings: Antibodies, Bacterial (*CH); Antigens, Bacterial (*IM); Crohn Disease (*IM/MI); Human; Mycobacterium paratuberculosis (*IM); Peptides (*IM); Recombinant Proteins (IM); Species Specificity; -RN-;
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| Journal Title Code:
CB7
| Publication Type:
JOURNAL ARTICLE
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| Date of Entry: 960116N | Entry Month: 9603
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| Country: UNITED STATES
| Index Priority: 2
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| Language: Eng
| Unique Identifier: 96050815
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| Unique Identifier: 96050815
| ISSN: 1071-412X
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| Abstract: Sera from patients with Crohn's disease and control were analyzed by an enzyme-linked immunosorbent assay based on the Mycobacterium paratuberculosis-specific recombinant polypeptide a362. Anti-a362 immunoglobulin G (IgG) (P < 0.05) and IgA (P < 0.001) titers were higher in patients with Crohn's disease than in controls. A monomodal Gaussian distribution of anti-a362 IgA levels were found for controls, and a bimodal distribution was found for patients with Crohn's disease. An M. paratuberculosis etiology is suggested for the 36% of patients with Crohn's disease who had an anti-a362 IgA level higher than that of controls.
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| Abstract By: Author
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| Address: Microbiology and Genetics Unit, University of Louvain, Brussels, Belgium.
|